Drug interactions
Cigarette smoking + Prochlorperazine
Severity: Minor
Cigarette smoking and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Smoking is not a drug, but components of tobacco smoke induce CYP1A2 and can lower plasma concentrations of some phenothiazines. Stopping smoking may raise levels and increase adverse effects.
What this interaction means in plain words
Cigarette smoking and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of hepatic metabolism, particularly CYP1A2, by polycyclic aromatic hydrocarbons in tobacco smoke.
What to do
Monitor response and sedation when smoking status changes, and adjust the prochlorperazine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Cigarette smoking with Prochlorperazine?
MediHelp rates the interaction as minor. Cigarette smoking and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Smoking is not a drug, but components of tobacco smoke induce CYP1A2 and can lower plasma concentrations of some phenothiazines. Stopping smoking may raise levels and increase adverse effects.
How serious is the interaction between Cigarette smoking and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and sedation when smoking status changes, and adjust the prochlorperazine dose if needed.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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