Drug interactions
Cilastatin-imipenem + Probenecid
Severity: Moderate
Cilastatin-imipenem and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid raises plasma concentrations and prolongs the half-life of imipenem and cilastatin. This may increase the risk of dose-related adverse effects such as seizures.
What this interaction means in plain words
Cilastatin-imipenem and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilastatin-imipenem belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular secretion of imipenem and cilastatin.
What to do
Coadministration is generally not recommended as it offers no therapeutic benefit. If used, monitor for neurotoxicity and adjust imipenem dose for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilastatin-imipenem
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Cilastatin-imipenem with Probenecid?
MediHelp rates the interaction as moderate. Cilastatin-imipenem and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid raises plasma concentrations and prolongs the half-life of imipenem and cilastatin. This may increase the risk of dose-related adverse effects such as seizures.
How serious is the interaction between Cilastatin-imipenem and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is generally not recommended as it offers no therapeutic benefit. If used, monitor for neurotoxicity and adjust imipenem dose for renal function.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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