Drug interactions
Cilostazol + Crizotinib
Severity: Moderate
Cilostazol and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may raise cilostazol and active metabolite concentrations. This could increase headache, tachycardia, palpitations and other dose-related effects.
What this interaction means in plain words
Cilostazol and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Crizotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by crizotinib reduces cilostazol clearance.
What to do
Consider reducing the cilostazol dose to 50 mg twice daily during coadministration and monitor heart rate and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Cilostazol with Crizotinib?
MediHelp rates the interaction as moderate. Cilostazol and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may raise cilostazol and active metabolite concentrations. This could increase headache, tachycardia, palpitations and other dose-related effects.
How serious is the interaction between Cilostazol and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the cilostazol dose to 50 mg twice daily during coadministration and monitor heart rate and adverse effects.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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