Drug interactions
Cilostazol + Darunavir
Severity: Moderate
Cilostazol and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a pharmacokinetic booster, strongly inhibits CYP3A4 and can raise cilostazol and its active metabolite exposure. This increases the risk of tachycardia, headache and other cilostazol adverse effects.
What this interaction means in plain words
Cilostazol and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 (boosted by ritonavir or cobicistat) reduces cilostazol clearance.
What to do
Consider reducing cilostazol to 50 mg twice daily when used with a strong CYP3A4 inhibitor, and monitor heart rate and symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Cilostazol with Darunavir?
MediHelp rates the interaction as moderate. Cilostazol and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with a pharmacokinetic booster, strongly inhibits CYP3A4 and can raise cilostazol and its active metabolite exposure. This increases the risk of tachycardia, headache and other cilostazol adverse effects.
How serious is the interaction between Cilostazol and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily when used with a strong CYP3A4 inhibitor, and monitor heart rate and symptoms.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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