Drug interactions
Cilostazol + Dasatinib
Severity: Moderate
Cilostazol and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor, so any rise in cilostazol exposure is likely small. Dasatinib also impairs platelet function and can cause bleeding, which may add to cilostazol's antiplatelet effect.
What this interaction means in plain words
Cilostazol and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Dasatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by dasatinib plus additive antiplatelet effects.
What to do
Monitor for bleeding and for cilostazol adverse effects such as headache and palpitations; reduce the cilostazol dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Cilostazol with Dasatinib?
MediHelp rates the interaction as moderate. Cilostazol and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak CYP3A4 inhibitor, so any rise in cilostazol exposure is likely small. Dasatinib also impairs platelet function and can cause bleeding, which may add to cilostazol's antiplatelet effect.
How serious is the interaction between Cilostazol and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and for cilostazol adverse effects such as headache and palpitations; reduce the cilostazol dose if these occur.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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