Drug interactions
Cilostazol + Etravirine
Severity: Moderate
Cilostazol and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 but inhibits CYP2C19, and cilostazol's active metabolites depend on both pathways. The net effect is uncertain, though CYP2C19 inhibition may raise levels of the active 3,4-dehydrocilostazol metabolite.
What this interaction means in plain words
Cilostazol and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Etravirine belongs to Anti Virals.
Why it happens
Etravirine inhibits CYP2C19 and induces CYP3A4, altering formation and clearance of cilostazol and its active metabolite.
What to do
Monitor for cilostazol adverse effects and consider reducing the dose to 50 mg twice daily if they occur. Reassess efficacy if the response seems diminished.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Cilostazol with Etravirine?
MediHelp rates the interaction as moderate. Cilostazol and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 but inhibits CYP2C19, and cilostazol's active metabolites depend on both pathways. The net effect is uncertain, though CYP2C19 inhibition may raise levels of the active 3,4-dehydrocilostazol metabolite.
How serious is the interaction between Cilostazol and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cilostazol adverse effects and consider reducing the dose to 50 mg twice daily if they occur. Reassess efficacy if the response seems diminished.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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