Drug interactions
Cilostazol + Fosaprepitant
Severity: Minor
Cilostazol and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor, but a single dose produces only a short, modest effect. A meaningful rise in cilostazol exposure is possible but typically transient.
What this interaction means in plain words
Cilostazol and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Temporary CYP3A4 inhibition by aprepitant reduces cilostazol metabolism.
What to do
Usually no adjustment is needed with single-dose use; monitor for headache or tachycardia during repeated chemotherapy cycles.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cilostazol
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Cilostazol with Fosaprepitant?
MediHelp rates the interaction as minor. Cilostazol and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor, but a single dose produces only a short, modest effect. A meaningful rise in cilostazol exposure is possible but typically transient.
How serious is the interaction between Cilostazol and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no adjustment is needed with single-dose use; monitor for headache or tachycardia during repeated chemotherapy cycles.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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