Drug interactions
Cilostazol + Letermovir
Severity: Moderate
Cilostazol and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A4 inhibitor and may increase cilostazol levels. This could increase cardiovascular and headache-type adverse effects.
What this interaction means in plain words
Cilostazol and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 by letermovir reduces cilostazol metabolism.
What to do
Monitor heart rate and tolerability; consider cilostazol 50 mg twice daily if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Cilostazol with Letermovir?
MediHelp rates the interaction as moderate. Cilostazol and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A4 inhibitor and may increase cilostazol levels. This could increase cardiovascular and headache-type adverse effects.
How serious is the interaction between Cilostazol and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and tolerability; consider cilostazol 50 mg twice daily if adverse effects develop.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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