Drug interactions
Cilostazol + Lomitapide
Severity: Moderate
Cilostazol and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal effects. Lomitapide has a narrow tolerability margin, and weak CYP3A4 inhibitors limit its dosing.
What this interaction means in plain words
Cilostazol and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by cilostazol reduces lomitapide metabolism.
What to do
Limit lomitapide dose per labeling when used with weak CYP3A4 inhibitors, and monitor liver enzymes and GI tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Cilostazol with Lomitapide?
MediHelp rates the interaction as moderate. Cilostazol and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cilostazol is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal effects. Lomitapide has a narrow tolerability margin, and weak CYP3A4 inhibitors limit its dosing.
How serious is the interaction between Cilostazol and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lomitapide dose per labeling when used with weak CYP3A4 inhibitors, and monitor liver enzymes and GI tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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