Drug interactions
Cilostazol + Omeprazole
Severity: Moderate
Cilostazol and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole inhibits CYP2C19 and raises exposure to cilostazol's active metabolite, increasing the risk of headache, tachycardia and palpitations. Cilostazol is contraindicated in heart failure, so excess exposure matters.
What this interaction means in plain words
Cilostazol and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole inhibits CYP2C19, reducing cilostazol metabolite clearance.
What to do
Reduce the cilostazol dose to 50 mg twice daily when used with omeprazole and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Omeprazole?
MediHelp rates the interaction as moderate. Cilostazol and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole inhibits CYP2C19 and raises exposure to cilostazol's active metabolite, increasing the risk of headache, tachycardia and palpitations. Cilostazol is contraindicated in heart failure, so excess exposure matters.
How serious is the interaction between Cilostazol and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cilostazol dose to 50 mg twice daily when used with omeprazole and monitor for adverse effects.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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