Drug interactions
Cilostazol + Ribociclib
Severity: Moderate
Cilostazol and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and can raise cilostazol and its active metabolite concentrations. This may amplify cilostazol effects such as tachycardia, headache and diarrhoea. Ribociclib also prolongs the QT interval, which adds a separate cardiac concern.
What this interaction means in plain words
Cilostazol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by ribociclib decreases cilostazol metabolism.
What to do
Consider reducing cilostazol to 50 mg twice daily during ribociclib therapy. Monitor heart rate, ECG and QT interval, and watch for adverse effects of cilostazol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Cilostazol with Ribociclib?
MediHelp rates the interaction as moderate. Cilostazol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and can raise cilostazol and its active metabolite concentrations. This may amplify cilostazol effects such as tachycardia, headache and diarrhoea. Ribociclib also prolongs the QT interval, which adds a separate cardiac concern.
How serious is the interaction between Cilostazol and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily during ribociclib therapy. Monitor heart rate, ECG and QT interval, and watch for adverse effects of cilostazol.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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