Drug interactions
Cilostazol + Rivaroxaban
Severity: Moderate
Cilostazol and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol has antiplatelet activity, so combined use with rivaroxaban increases the risk of bleeding.
What this interaction means in plain words
Cilostazol and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive hemostatic effects from phosphodiesterase-3-mediated platelet inhibition and factor Xa inhibition.
What to do
Monitor for bleeding and hemoglobin changes. Reassess the need for cilostazol if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Rivaroxaban?
MediHelp rates the interaction as moderate. Cilostazol and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cilostazol has antiplatelet activity, so combined use with rivaroxaban increases the risk of bleeding.
How serious is the interaction between Cilostazol and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin changes. Reassess the need for cilostazol if bleeding occurs.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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