Drug interactions
Cilostazol + Voriconazole
Severity: Moderate
Cilostazol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can increase cilostazol and active metabolite exposure, raising the risk of headache, tachycardia, palpitations and hypotension. Cilostazol is contraindicated in heart failure, so excess exposure is a concern.
What this interaction means in plain words
Cilostazol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 and CYP2C19, which metabolize cilostazol.
What to do
Reduce the cilostazol dose to 50 mg twice daily during voriconazole therapy, as labeling advises for strong CYP3A4 or CYP2C19 inhibitors. Monitor for tachycardia and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Voriconazole?
MediHelp rates the interaction as moderate. Cilostazol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can increase cilostazol and active metabolite exposure, raising the risk of headache, tachycardia, palpitations and hypotension. Cilostazol is contraindicated in heart failure, so excess exposure is a concern.
How serious is the interaction between Cilostazol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cilostazol dose to 50 mg twice daily during voriconazole therapy, as labeling advises for strong CYP3A4 or CYP2C19 inhibitors. Monitor for tachycardia and adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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