Drug interactions
Cimetidine + Cinacalcet
Severity: Minor
Cimetidine and Cinacalcet: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase cinacalcet exposure by weakly inhibiting CYP3A4, which could lead to hypocalcemia or gastrointestinal effects. Clinical significance is likely limited.
What this interaction means in plain words
Cimetidine and Cinacalcet have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Cinacalcet belongs to Miscellaneous.
Why it happens
Cimetidine weakly inhibits CYP3A4 metabolism of cinacalcet.
What to do
Monitor serum calcium and parathyroid hormone, and adjust the cinacalcet dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cimetidine with Cinacalcet?
MediHelp rates the interaction as minor. Cimetidine and Cinacalcet have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may increase cinacalcet exposure by weakly inhibiting CYP3A4, which could lead to hypocalcemia or gastrointestinal effects. Clinical significance is likely limited.
How serious is the interaction between Cimetidine and Cinacalcet?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and parathyroid hormone, and adjust the cinacalcet dose if needed.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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