Drug interactions
Cimetidine + Clorazepate
Severity: Moderate
Cimetidine and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may raise levels of the active metabolite of clorazepate, nordazepam, and prolong its sedative effect. Elderly patients are most at risk of excessive sedation.
What this interaction means in plain words
Cimetidine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Clorazepate belongs to Central Nervous System.
Why it happens
Cimetidine inhibits hepatic oxidative metabolism of nordazepam.
What to do
Monitor sedation and psychomotor function and lower the clorazepate dose if needed. Consider famotidine instead of cimetidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Cimetidine with Clorazepate?
MediHelp rates the interaction as moderate. Cimetidine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may raise levels of the active metabolite of clorazepate, nordazepam, and prolong its sedative effect. Elderly patients are most at risk of excessive sedation.
How serious is the interaction between Cimetidine and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychomotor function and lower the clorazepate dose if needed. Consider famotidine instead of cimetidine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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