Drug interactions
Cimetidine + Dronedarone
Severity: Moderate
Cimetidine and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak to moderate CYP3A4 inhibitor and may increase dronedarone concentrations. Higher exposure raises the risk of QT prolongation, bradycardia and gastrointestinal effects.
What this interaction means in plain words
Cimetidine and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Dronedarone belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated dronedarone metabolism by cimetidine.
What to do
Monitor ECG and heart rate, or prefer famotidine, which lacks CYP inhibition, for acid suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Cimetidine with Dronedarone?
MediHelp rates the interaction as moderate. Cimetidine and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine is a weak to moderate CYP3A4 inhibitor and may increase dronedarone concentrations. Higher exposure raises the risk of QT prolongation, bradycardia and gastrointestinal effects.
How serious is the interaction between Cimetidine and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, or prefer famotidine, which lacks CYP inhibition, for acid suppression.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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