Drug interactions
Cimetidine + Eliglustat
Severity: Major
Cimetidine and Eliglustat: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine, a CYP2D6 and CYP3A inhibitor, can raise eliglustat exposure, increasing the risk of PR, QRS and QT prolongation and arrhythmia. The combination is especially hazardous when both CYP2D6 and CYP3A are inhibited.
What this interaction means in plain words
Cimetidine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Eliglustat belongs to Miscellaneous.
Why it happens
Cimetidine inhibits CYP2D6 and CYP3A4, the main enzymes metabolizing eliglustat.
What to do
Avoid in CYP2D6 poor metabolizers and consider an alternative acid suppressant such as famotidine. Otherwise reduce eliglustat dose per labeling and monitor ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Cimetidine with Eliglustat?
MediHelp rates the interaction as major. Cimetidine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine, a CYP2D6 and CYP3A inhibitor, can raise eliglustat exposure, increasing the risk of PR, QRS and QT prolongation and arrhythmia. The combination is especially hazardous when both CYP2D6 and CYP3A are inhibited.
How serious is the interaction between Cimetidine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 poor metabolizers and consider an alternative acid suppressant such as famotidine. Otherwise reduce eliglustat dose per labeling and monitor ECG.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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