Drug interactions
Cimetidine + Eslicarbazepine
Severity: Minor
Cimetidine and Eslicarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may inhibit CYP2C19 and could modestly raise levels of drugs metabolized by it. Cimetidine is only partly dependent on this pathway, so a clinically important effect is unlikely.
What this interaction means in plain words
Cimetidine and Eslicarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine is a weak CYP2C19 inhibitor, though cimetidine is cleared mainly by renal secretion.
What to do
No dose adjustment is needed. Monitor for cimetidine adverse effects if the clinical picture suggests accumulation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Eslicarbazepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Cimetidine with Eslicarbazepine?
MediHelp rates the interaction as minor. Cimetidine and Eslicarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eslicarbazepine may inhibit CYP2C19 and could modestly raise levels of drugs metabolized by it. Cimetidine is only partly dependent on this pathway, so a clinically important effect is unlikely.
How serious is the interaction between Cimetidine and Eslicarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for cimetidine adverse effects if the clinical picture suggests accumulation.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
