Drug interactions
Cimetidine + Etravirine
Severity: Minor
Cimetidine and Etravirine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase etravirine levels. Etravirine has a wide safety margin, so clinically important toxicity is unlikely.
What this interaction means in plain words
Cimetidine and Etravirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Etravirine belongs to Anti Virals.
Why it happens
Cimetidine may inhibit CYP3A4 and CYP2C19, which metabolize etravirine.
What to do
No dose adjustment is generally required; monitor for rash and other etravirine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Cimetidine with Etravirine?
MediHelp rates the interaction as minor. Cimetidine and Etravirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may increase etravirine levels. Etravirine has a wide safety margin, so clinically important toxicity is unlikely.
How serious is the interaction between Cimetidine and Etravirine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for rash and other etravirine adverse effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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