Drug interactions
Cimetidine + Flibanserin
Severity: Major
Cimetidine and Flibanserin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can increase flibanserin exposure, raising the risk of hypotension, syncope and sedation. Flibanserin labeling warns about use with multiple weak CYP3A4 inhibitors.
What this interaction means in plain words
Cimetidine and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Flibanserin belongs to Genitourinary.
Why it happens
Cimetidine inhibits CYP3A4 and other CYPs, decreasing flibanserin clearance.
What to do
Avoid the combination where possible, using famotidine as an alternative. If used, monitor for hypotension and sedation, and avoid alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Cimetidine with Flibanserin?
MediHelp rates the interaction as major. Cimetidine and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine can increase flibanserin exposure, raising the risk of hypotension, syncope and sedation. Flibanserin labeling warns about use with multiple weak CYP3A4 inhibitors.
How serious is the interaction between Cimetidine and Flibanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using famotidine as an alternative. If used, monitor for hypotension and sedation, and avoid alcohol.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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