Drug interactions
Cimetidine + Fluvoxamine
Severity: Minor
Cimetidine and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is not expected to increase cimetidine meaningfully because cimetidine is mostly renally eliminated. Cimetidine could raise fluvoxamine concentrations modestly through CYP inhibition, with limited clinical significance.
What this interaction means in plain words
Cimetidine and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Fluvoxamine belongs to Central Nervous System.
Why it happens
Cimetidine's nonspecific CYP inhibition may slightly decrease fluvoxamine clearance; no relevant effect on cimetidine is established.
What to do
No routine action; monitor for fluvoxamine adverse effects such as nausea or sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Cimetidine with Fluvoxamine?
MediHelp rates the interaction as minor. Cimetidine and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine is not expected to increase cimetidine meaningfully because cimetidine is mostly renally eliminated. Cimetidine could raise fluvoxamine concentrations modestly through CYP inhibition, with limited clinical significance.
How serious is the interaction between Cimetidine and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; monitor for fluvoxamine adverse effects such as nausea or sedation.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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