Drug interactions
Cimetidine + Hydromorphone
Severity: Minor
Cimetidine and Hydromorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydromorphone is cleared mainly by glucuronidation, not CYP enzymes, so cimetidine is unlikely to have a significant effect on it.
What this interaction means in plain words
Cimetidine and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Hydromorphone belongs to Musculoskeletal.
Why it happens
No established pharmacokinetic mechanism; hydromorphone is metabolized by UGT2B7.
What to do
No specific action needed; monitor usual opioid effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Cimetidine with Hydromorphone?
MediHelp rates the interaction as minor. Cimetidine and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydromorphone is cleared mainly by glucuronidation, not CYP enzymes, so cimetidine is unlikely to have a significant effect on it.
How serious is the interaction between Cimetidine and Hydromorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed; monitor usual opioid effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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