Drug interactions
Cimetidine + Lurasidone
Severity: Moderate
Cimetidine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak to moderate CYP3A4 inhibitor and may raise lurasidone exposure. This increases the risk of dose-related adverse effects such as akathisia, sedation and parkinsonism.
What this interaction means in plain words
Cimetidine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Lurasidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 reduces first-pass and systemic metabolism of lurasidone.
What to do
Monitor for lurasidone adverse effects and keep to the lower dose limits recommended with moderate CYP3A4 inhibitors. Consider famotidine as an alternative to cimetidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Cimetidine with Lurasidone?
MediHelp rates the interaction as moderate. Cimetidine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine is a weak to moderate CYP3A4 inhibitor and may raise lurasidone exposure. This increases the risk of dose-related adverse effects such as akathisia, sedation and parkinsonism.
How serious is the interaction between Cimetidine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lurasidone adverse effects and keep to the lower dose limits recommended with moderate CYP3A4 inhibitors. Consider famotidine as an alternative to cimetidine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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