Drug interactions
Cimetidine + Metoprolol
Severity: Moderate
Cimetidine and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can increase metoprolol exposure and enhance its beta-blocking effects. This may cause excess bradycardia or hypotension.
What this interaction means in plain words
Cimetidine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Metoprolol belongs to Cardiovascular.
Why it happens
Cimetidine inhibits CYP2D6 metabolism of metoprolol and may reduce hepatic blood flow.
What to do
Monitor heart rate and blood pressure when starting or stopping cimetidine, and reduce the metoprolol dose if needed. Alternatively use famotidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Cimetidine with Metoprolol?
MediHelp rates the interaction as moderate. Cimetidine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine can increase metoprolol exposure and enhance its beta-blocking effects. This may cause excess bradycardia or hypotension.
How serious is the interaction between Cimetidine and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping cimetidine, and reduce the metoprolol dose if needed. Alternatively use famotidine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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