Drug interactions
Cimetidine + Nicotine
Severity: Minor
Cimetidine and Nicotine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may reduce nicotine clearance and modestly raise nicotine levels. The clinical effect is generally small, with possible nausea, dizziness or palpitations with nicotine replacement.
What this interaction means in plain words
Cimetidine and Nicotine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Nicotine belongs to Respiratory.
Why it happens
Cimetidine reduces nicotine clearance, possibly via inhibition of hepatic metabolism and renal tubular secretion.
What to do
Usually no adjustment needed; monitor for nicotine excess and reduce the replacement dose if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicotine
- Adenosine + Nicotine Moderate
- Bupropion + Nicotine Moderate
- Dihydroergotamine intranasal + Nicotine Moderate
- Dihydroergotamine + Nicotine Moderate
- Esketamine intranasal + Nicotine Moderate
- Nicotine + Solriamfetol Moderate
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Nicotine?
MediHelp rates the interaction as minor. Cimetidine and Nicotine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may reduce nicotine clearance and modestly raise nicotine levels. The clinical effect is generally small, with possible nausea, dizziness or palpitations with nicotine replacement.
How serious is the interaction between Cimetidine and Nicotine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no adjustment needed; monitor for nicotine excess and reduce the replacement dose if symptoms appear.
What other medicines interact with Nicotine?
MediHelp also lists interactions of Nicotine with, for example, Adenosine, Bupropion, Dihydroergotamine intranasal. The full list is on the Nicotine page.
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