Drug interactions
Cimetidine + Ospemifene
Severity: Minor
Cimetidine and Ospemifene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may raise ospemifene levels by inhibiting its metabolism. The effect is modest, and the clinical importance is uncertain.
What this interaction means in plain words
Cimetidine and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Ospemifene belongs to Endocrine.
Why it happens
Cimetidine inhibits CYP3A4 and CYP2C19, which metabolize ospemifene.
What to do
No routine adjustment is needed; monitor for ospemifene adverse effects such as hot flashes or vaginal discharge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Cimetidine with Ospemifene?
MediHelp rates the interaction as minor. Cimetidine and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may raise ospemifene levels by inhibiting its metabolism. The effect is modest, and the clinical importance is uncertain.
How serious is the interaction between Cimetidine and Ospemifene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for ospemifene adverse effects such as hot flashes or vaginal discharge.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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