Drug interactions
Cimetidine + Piroxicam
Severity: Minor
Cimetidine and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may slightly raise piroxicam exposure, though no clinically relevant change has been firmly demonstrated.
What this interaction means in plain words
Cimetidine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Piroxicam belongs to Musculoskeletal.
Why it happens
Cimetidine weakly inhibits CYP2C9, which metabolizes piroxicam.
What to do
No routine adjustment is needed; monitor for gastrointestinal and renal adverse effects given piroxicam's long half-life.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Cimetidine with Piroxicam?
MediHelp rates the interaction as minor. Cimetidine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may slightly raise piroxicam exposure, though no clinically relevant change has been firmly demonstrated.
How serious is the interaction between Cimetidine and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for gastrointestinal and renal adverse effects given piroxicam's long half-life.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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