Drug interactions
Cimetidine + Sonidegib
Severity: Moderate
Cimetidine and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase sonidegib exposure through CYP3A4 inhibition. Higher exposure raises the risk of adverse effects, particularly musculoskeletal toxicity such as CK elevation and myopathy.
What this interaction means in plain words
Cimetidine and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Sonidegib belongs to Oncology.
Why it happens
Cimetidine inhibits CYP3A4, which metabolizes sonidegib.
What to do
Avoid if possible, or use an alternative acid suppressant such as a proton pump inhibitor or famotidine. If unavoidable, limit cimetidine to under 14 days and monitor for muscle symptoms and CK.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Cimetidine with Sonidegib?
MediHelp rates the interaction as moderate. Cimetidine and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may increase sonidegib exposure through CYP3A4 inhibition. Higher exposure raises the risk of adverse effects, particularly musculoskeletal toxicity such as CK elevation and myopathy.
How serious is the interaction between Cimetidine and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use an alternative acid suppressant such as a proton pump inhibitor or famotidine. If unavoidable, limit cimetidine to under 14 days and monitor for muscle symptoms and CK.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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