Drug interactions
Cimetidine + Tafamidis
Severity: Minor
Cimetidine and Tafamidis: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and could raise exposure to BCRP substrates. Cimetidine is not a major BCRP substrate, so a meaningful effect is unlikely.
What this interaction means in plain words
Cimetidine and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Tafamidis belongs to Cardiovascular.
Why it happens
BCRP inhibition by tafamidis may slightly increase cimetidine exposure.
What to do
No adjustment is needed in most patients; monitor for cimetidine adverse effects if clinically suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Cimetidine with Tafamidis?
MediHelp rates the interaction as minor. Cimetidine and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis inhibits BCRP in vitro and could raise exposure to BCRP substrates. Cimetidine is not a major BCRP substrate, so a meaningful effect is unlikely.
How serious is the interaction between Cimetidine and Tafamidis?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed in most patients; monitor for cimetidine adverse effects if clinically suspected.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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