Drug interactions
Cimetidine + Tapentadol
Severity: Minor
Cimetidine and Tapentadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No meaningful interaction is expected between these drugs. Tapentadol is mainly cleared by glucuronidation with little CYP involvement, so cimetidine is unlikely to change its exposure.
What this interaction means in plain words
Cimetidine and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Tapentadol belongs to Musculoskeletal.
Why it happens
Tapentadol is metabolized mainly by UGT glucuronidation, so cimetidine's CYP inhibition is unlikely to alter its clearance.
What to do
No action is required beyond routine monitoring of opioid effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Frequently asked questions
Can I take Cimetidine with Tapentadol?
MediHelp rates the interaction as minor. Cimetidine and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No meaningful interaction is expected between these drugs. Tapentadol is mainly cleared by glucuronidation with little CYP involvement, so cimetidine is unlikely to change its exposure.
How serious is the interaction between Cimetidine and Tapentadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required beyond routine monitoring of opioid effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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