Drug interactions
Cimetidine + Tipranavir
Severity: Minor
Cimetidine and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak CYP3A4 inhibitor, but tipranavir is always given with ritonavir, which already strongly modulates CYP3A, so additional effect from cimetidine is likely small. No significant clinical interaction is established.
What this interaction means in plain words
Cimetidine and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Tipranavir belongs to Anti Virals.
Why it happens
Cimetidine weakly inhibits CYP3A4, which could slightly reduce tipranavir metabolism, though ritonavir boosting dominates.
What to do
No dose adjustment is generally needed; monitor for tipranavir adverse effects such as liver enzyme elevations as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Cimetidine with Tipranavir?
MediHelp rates the interaction as minor. Cimetidine and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is a weak CYP3A4 inhibitor, but tipranavir is always given with ritonavir, which already strongly modulates CYP3A, so additional effect from cimetidine is likely small. No significant clinical interaction is established.
How serious is the interaction between Cimetidine and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for tipranavir adverse effects such as liver enzyme elevations as part of routine care.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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