Drug interactions
Cimetidine + Voriconazole
Severity: Minor
Cimetidine and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit CYP enzymes, so each could modestly raise exposure to the other. In practice the changes are small and rarely clinically meaningful.
What this interaction means in plain words
Cimetidine and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Cimetidine weakly inhibits CYP2C19 and CYP3A4 while voriconazole inhibits CYP2C19, CYP2C9 and CYP3A4, so mutual metabolic inhibition is possible.
What to do
No dose adjustment is usually required; monitor for voriconazole adverse effects such as visual disturbance, hepatotoxicity or QT prolongation if the combination is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Cimetidine with Voriconazole?
MediHelp rates the interaction as minor. Cimetidine and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs inhibit CYP enzymes, so each could modestly raise exposure to the other. In practice the changes are small and rarely clinically meaningful.
How serious is the interaction between Cimetidine and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for voriconazole adverse effects such as visual disturbance, hepatotoxicity or QT prolongation if the combination is used long term.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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