Drug interactions
Cinacalcet + Deutetrabenazine
Severity: Moderate
Cinacalcet and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor and deutetrabenazine's active metabolites are cleared by CYP2D6. Exposure to these metabolites rises substantially, increasing the risk of dose-related adverse effects such as sedation, depression, parkinsonism and QT prolongation.
What this interaction means in plain words
Cinacalcet and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 by cinacalcet reduces metabolism of the active dihydro-metabolites of deutetrabenazine.
What to do
Limit deutetrabenazine to no more than 18 mg per dose and 36 mg per day while cinacalcet is used. Monitor for somnolence, mood changes and QT-related symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Cinacalcet with Deutetrabenazine?
MediHelp rates the interaction as moderate. Cinacalcet and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is a strong CYP2D6 inhibitor and deutetrabenazine's active metabolites are cleared by CYP2D6. Exposure to these metabolites rises substantially, increasing the risk of dose-related adverse effects such as sedation, depression, parkinsonism and QT prolongation.
How serious is the interaction between Cinacalcet and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit deutetrabenazine to no more than 18 mg per dose and 36 mg per day while cinacalcet is used. Monitor for somnolence, mood changes and QT-related symptoms.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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