Drug interactions
Cinacalcet + Lapatinib
Severity: Minor
Cinacalcet and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may modestly increase cinacalcet exposure by inhibiting CYP3A4, though cinacalcet is also cleared by CYP2D6 and CYP1A2. Hypocalcemia or gastrointestinal effects may be more likely.
What this interaction means in plain words
Cinacalcet and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4 involved in cinacalcet metabolism.
What to do
Monitor serum calcium and adjust cinacalcet dose as indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Lapatinib?
MediHelp rates the interaction as minor. Cinacalcet and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib may modestly increase cinacalcet exposure by inhibiting CYP3A4, though cinacalcet is also cleared by CYP2D6 and CYP1A2. Hypocalcemia or gastrointestinal effects may be more likely.
How serious is the interaction between Cinacalcet and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and adjust cinacalcet dose as indicated.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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