Drug interactions
Cinacalcet + Oliceridine
Severity: Moderate
Cinacalcet and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized mainly by CYP3A4 and CYP2D6, and cinacalcet strongly inhibits CYP2D6. Higher oliceridine exposure may increase opioid effects including sedation and respiratory depression.
What this interaction means in plain words
Cinacalcet and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Oliceridine belongs to Musculoskeletal.
Why it happens
Cinacalcet inhibits CYP2D6, reducing oliceridine metabolism.
What to do
Use less frequent or lower oliceridine doses and monitor for sedation and respiratory depression. If cinacalcet is stopped, reassess the oliceridine dose and watch for reduced analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Cinacalcet with Oliceridine?
MediHelp rates the interaction as moderate. Cinacalcet and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is metabolized mainly by CYP3A4 and CYP2D6, and cinacalcet strongly inhibits CYP2D6. Higher oliceridine exposure may increase opioid effects including sedation and respiratory depression.
How serious is the interaction between Cinacalcet and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use less frequent or lower oliceridine doses and monitor for sedation and respiratory depression. If cinacalcet is stopped, reassess the oliceridine dose and watch for reduced analgesia.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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