Drug interactions
Cinacalcet + Tamsulosin
Severity: Moderate
Cinacalcet and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor and can increase exposure to tamsulosin. This may lead to more dizziness and orthostatic hypotension.
What this interaction means in plain words
Cinacalcet and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Tamsulosin belongs to Genitourinary.
Why it happens
Strong CYP2D6 inhibition by cinacalcet decreases tamsulosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms after starting or adjusting cinacalcet. Consider reducing the tamsulosin dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Tamsulosin?
MediHelp rates the interaction as moderate. Cinacalcet and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is a strong CYP2D6 inhibitor and can increase exposure to tamsulosin. This may lead to more dizziness and orthostatic hypotension.
How serious is the interaction between Cinacalcet and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms after starting or adjusting cinacalcet. Consider reducing the tamsulosin dose if adverse effects arise.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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