Drug interactions
Cinacalcet + Terbinafine
Severity: Moderate
Cinacalcet and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a CYP2D6 substrate and a strong CYP2D6 inhibitor such as terbinafine can raise its levels. This may increase the risk of hypocalcemia and gastrointestinal adverse effects.
What this interaction means in plain words
Cinacalcet and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Terbinafine belongs to Anti Fungals.
Why it happens
CYP2D6 inhibition by terbinafine reduces cinacalcet clearance, as CYP3A4 and CYP1A2 also contribute.
What to do
Monitor serum calcium and PTH and adjust cinacalcet dose if hypocalcemia or intolerance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Terbinafine?
MediHelp rates the interaction as moderate. Cinacalcet and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is a CYP2D6 substrate and a strong CYP2D6 inhibitor such as terbinafine can raise its levels. This may increase the risk of hypocalcemia and gastrointestinal adverse effects.
How serious is the interaction between Cinacalcet and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH and adjust cinacalcet dose if hypocalcemia or intolerance develops.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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