Drug interactions
Cinacalcet + Zafirlukast
Severity: Minor
Cinacalcet and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is metabolized by several enzymes including CYP3A4, so a weak inhibitor like zafirlukast is unlikely to cause a meaningful rise. Increased levels could worsen nausea or hypocalcemia.
What this interaction means in plain words
Cinacalcet and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may slightly reduce cinacalcet metabolism.
What to do
Monitor serum calcium and PTH as per routine practice. Adjust cinacalcet dose only if hypocalcemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Zafirlukast?
MediHelp rates the interaction as minor. Cinacalcet and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinacalcet is metabolized by several enzymes including CYP3A4, so a weak inhibitor like zafirlukast is unlikely to cause a meaningful rise. Increased levels could worsen nausea or hypocalcemia.
How serious is the interaction between Cinacalcet and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH as per routine practice. Adjust cinacalcet dose only if hypocalcemia occurs.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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