Drug interactions
Cinnarizine + Cyclizine
Severity: Moderate
Cinnarizine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating antihistamines used for nausea and vertigo. Together they increase drowsiness and anticholinergic effects, and cinnarizine may cause extrapyramidal symptoms in susceptible patients.
What this interaction means in plain words
Cinnarizine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Cyclizine belongs to Respiratory.
Why it happens
Additive H1-receptor and muscarinic blockade with CNS depression.
What to do
Avoid duplicate antihistamine antiemetic therapy and choose one agent. Monitor older patients for oversedation, falls and movement disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Cyclizine?
MediHelp rates the interaction as moderate. Cinnarizine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating antihistamines used for nausea and vertigo. Together they increase drowsiness and anticholinergic effects, and cinnarizine may cause extrapyramidal symptoms in susceptible patients.
How serious is the interaction between Cinnarizine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antihistamine antiemetic therapy and choose one agent. Monitor older patients for oversedation, falls and movement disorders.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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