Drug interactions
Cinnarizine + Loxapine
Severity: Moderate
Cinnarizine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine has sedative antihistaminic properties and may itself cause extrapyramidal symptoms, particularly in older patients. Combined with loxapine, it can increase drowsiness and worsen parkinsonian features.
What this interaction means in plain words
Cinnarizine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1 blockade, with cinnarizine contributing weak dopamine D2 antagonism that adds to loxapine's effect.
What to do
Monitor for sedation and new or worsening extrapyramidal symptoms, especially in the elderly. Use the lowest effective cinnarizine dose or choose an alternative if movement symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Loxapine?
MediHelp rates the interaction as moderate. Cinnarizine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine has sedative antihistaminic properties and may itself cause extrapyramidal symptoms, particularly in older patients. Combined with loxapine, it can increase drowsiness and worsen parkinsonian features.
How serious is the interaction between Cinnarizine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and new or worsening extrapyramidal symptoms, especially in the elderly. Use the lowest effective cinnarizine dose or choose an alternative if movement symptoms appear.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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