Drug interactions
Cinnarizine + Maprotiline
Severity: Moderate
Cinnarizine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker with some anticholinergic activity, and maprotiline has similar sedative properties. Combined use can increase drowsiness and impair psychomotor performance. Cinnarizine can also cause extrapyramidal symptoms and depression, which may be relevant in this setting.
What this interaction means in plain words
Cinnarizine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from H1 receptor blockade.
What to do
Use the lowest effective doses and warn the patient about drowsiness and driving. Review the need for both drugs if sedation or movement symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Maprotiline?
MediHelp rates the interaction as moderate. Cinnarizine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker with some anticholinergic activity, and maprotiline has similar sedative properties. Combined use can increase drowsiness and impair psychomotor performance. Cinnarizine can also cause extrapyramidal symptoms and depression, which may be relevant in this setting.
How serious is the interaction between Cinnarizine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn the patient about drowsiness and driving. Review the need for both drugs if sedation or movement symptoms develop.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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