Drug interactions
Cinnarizine + Methocarbamol
Severity: Moderate
Cinnarizine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker, and methocarbamol is a sedating muscle relaxant. Used together they may cause greater drowsiness, dizziness and reduced alertness than either alone.
What this interaction means in plain words
Cinnarizine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of a sedating H1 antihistamine and a centrally acting muscle relaxant.
What to do
Monitor for excessive sedation and counsel patients to avoid driving or hazardous tasks. Consider reducing the dose of one agent if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cinnarizine and Methocarbamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methocarbamol
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Methocarbamol?
MediHelp rates the interaction as moderate. Cinnarizine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker, and methocarbamol is a sedating muscle relaxant. Used together they may cause greater drowsiness, dizziness and reduced alertness than either alone.
How serious is the interaction between Cinnarizine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients to avoid driving or hazardous tasks. Consider reducing the dose of one agent if drowsiness is troublesome.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
