Drug interactions
Cinnarizine + Nalbuphine
Severity: Moderate
Cinnarizine and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker, and it may add to the drowsiness caused by nalbuphine. Impaired alertness and coordination may result.
What this interaction means in plain words
Cinnarizine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 antagonism and opioid activity.
What to do
Monitor for excessive sedation and adjust doses as needed. Counsel the patient about driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Nalbuphine?
MediHelp rates the interaction as moderate. Cinnarizine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker, and it may add to the drowsiness caused by nalbuphine. Impaired alertness and coordination may result.
How serious is the interaction between Cinnarizine and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and adjust doses as needed. Counsel the patient about driving and machinery.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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