Drug interactions
Cinnarizine + Quetiapine
Severity: Moderate
Cinnarizine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, so combined use may increase sedation and impair psychomotor performance. Cinnarizine can also cause extrapyramidal symptoms, which may be additive with antipsychotic dopamine blockade.
What this interaction means in plain words
Cinnarizine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1 antagonism, with additive dopamine D2 blockade.
What to do
Counsel about sedation and monitor for parkinsonian symptoms, especially in elderly patients; use the lowest effective cinnarizine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Quetiapine?
MediHelp rates the interaction as moderate. Cinnarizine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, so combined use may increase sedation and impair psychomotor performance. Cinnarizine can also cause extrapyramidal symptoms, which may be additive with antipsychotic dopamine blockade.
How serious is the interaction between Cinnarizine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about sedation and monitor for parkinsonian symptoms, especially in elderly patients; use the lowest effective cinnarizine dose.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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