Drug interactions
Cinnarizine + Thioridazine
Severity: Moderate
Cinnarizine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and each can produce extrapyramidal symptoms. Cinnarizine has been associated with parkinsonism, which may be aggravated by a dopamine-blocking phenothiazine. Additive drowsiness may impair driving and increase falls.
What this interaction means in plain words
Cinnarizine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and dopamine antagonism, with antihistaminic and calcium channel blocking effects of cinnarizine.
What to do
Monitor for sedation and new tremor, rigidity or other extrapyramidal signs. Use the lowest effective doses and stop cinnarizine if parkinsonism emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Thioridazine?
MediHelp rates the interaction as moderate. Cinnarizine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and each can produce extrapyramidal symptoms. Cinnarizine has been associated with parkinsonism, which may be aggravated by a dopamine-blocking phenothiazine. Additive drowsiness may impair driving and increase falls.
How serious is the interaction between Cinnarizine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and new tremor, rigidity or other extrapyramidal signs. Use the lowest effective doses and stop cinnarizine if parkinsonism emerges.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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