Drug interactions
Cinnarizine + Ziprasidone
Severity: Moderate
Cinnarizine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause drowsiness through central histamine H1 and other receptor blockade, so combined use can deepen sedation and impair alertness and psychomotor performance. Cinnarizine may also add to extrapyramidal effects in susceptible patients.
What this interaction means in plain words
Cinnarizine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through H1 antagonism and other receptor blockade.
What to do
Warn patients about impaired driving and machinery use, and start with the lowest cinnarizine dose. Reduce doses or stop one agent if excessive sedation or movement disorders occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Ziprasidone?
MediHelp rates the interaction as moderate. Cinnarizine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause drowsiness through central histamine H1 and other receptor blockade, so combined use can deepen sedation and impair alertness and psychomotor performance. Cinnarizine may also add to extrapyramidal effects in susceptible patients.
How serious is the interaction between Cinnarizine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about impaired driving and machinery use, and start with the lowest cinnarizine dose. Reduce doses or stop one agent if excessive sedation or movement disorders occur.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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