Drug interactions
Ciprofloxacin + Corticotropin
Severity: Moderate
Ciprofloxacin and Corticotropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones carry a risk of tendinopathy and tendon rupture, which is increased by systemic corticosteroids. Corticotropin raises endogenous corticosteroid levels and is expected to add to this risk, especially in older patients.
What this interaction means in plain words
Ciprofloxacin and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Corticotropin belongs to Endocrine.
Why it happens
Additive tendon toxicity from fluoroquinolone effects on tendon tissue and corticosteroid-induced collagen impairment.
What to do
Counsel patients to stop ciprofloxacin and rest if tendon pain or swelling develops. Consider an alternative antibiotic in older patients or those on prolonged corticotropin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Ciprofloxacin with Corticotropin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones carry a risk of tendinopathy and tendon rupture, which is increased by systemic corticosteroids. Corticotropin raises endogenous corticosteroid levels and is expected to add to this risk, especially in older patients.
How serious is the interaction between Ciprofloxacin and Corticotropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to stop ciprofloxacin and rest if tendon pain or swelling develops. Consider an alternative antibiotic in older patients or those on prolonged corticotropin.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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