Drug interactions
Ciprofloxacin + Dasatinib
Severity: Moderate
Ciprofloxacin and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib and ciprofloxacin may both prolong the QT interval, so together they may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with hypokalemia, hypomagnesemia, bradycardia or structural heart disease.
What this interaction means in plain words
Ciprofloxacin and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Dasatinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization via potassium channel effects.
What to do
Correct electrolytes before and during therapy and obtain a baseline ECG with follow-up QTc checks. Consider an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Ciprofloxacin with Dasatinib?
MediHelp rates the interaction as moderate. Ciprofloxacin and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib and ciprofloxacin may both prolong the QT interval, so together they may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with hypokalemia, hypomagnesemia, bradycardia or structural heart disease.
How serious is the interaction between Ciprofloxacin and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolytes before and during therapy and obtain a baseline ECG with follow-up QTc checks. Consider an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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