Drug interactions
Ciprofloxacin + Eluxadoline
Severity: Minor
Ciprofloxacin and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin inhibits CYP1A2, and eluxadoline metabolism is incompletely characterized, so exposure to eluxadoline may rise. The clinical effect is uncertain.
What this interaction means in plain words
Ciprofloxacin and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of CYP1A2-mediated metabolism of eluxadoline by ciprofloxacin; this is not well established.
What to do
No dose change is routinely required. Monitor for eluxadoline effects such as constipation, nausea or abdominal pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Ciprofloxacin with Eluxadoline?
MediHelp rates the interaction as minor. Ciprofloxacin and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin inhibits CYP1A2, and eluxadoline metabolism is incompletely characterized, so exposure to eluxadoline may rise. The clinical effect is uncertain.
How serious is the interaction between Ciprofloxacin and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required. Monitor for eluxadoline effects such as constipation, nausea or abdominal pain.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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