Drug interactions
Ciprofloxacin + Gilteritinib
Severity: Moderate
Ciprofloxacin and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval and ciprofloxacin adds a smaller QT effect. The combination raises the possibility of torsades de pointes, especially in leukaemia patients who often have electrolyte abnormalities.
What this interaction means in plain words
Ciprofloxacin and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Gilteritinib belongs to Oncology.
Why it happens
Additive QT prolongation; ciprofloxacin may also modestly raise gilteritinib exposure via CYP3A4 or P-gp inhibition, though this is not well characterised.
What to do
Monitor ECG at baseline and periodically during co-therapy and keep potassium and magnesium within normal range. Consider an alternative antibiotic if the QTc rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Ciprofloxacin with Gilteritinib?
MediHelp rates the interaction as moderate. Ciprofloxacin and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib can prolong the QT interval and ciprofloxacin adds a smaller QT effect. The combination raises the possibility of torsades de pointes, especially in leukaemia patients who often have electrolyte abnormalities.
How serious is the interaction between Ciprofloxacin and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG at baseline and periodically during co-therapy and keep potassium and magnesium within normal range. Consider an alternative antibiotic if the QTc rises markedly.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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